Harper Adams University Repository

Cadmium, lead, and arsenic contamination in paddy soils of a mining area and their exposure effects on human HEPG2 and keratinocyte cell-lines

Xue, S., Shi, L., Wu, C., Wu, H., Qin, Y., Pan, W., Hartley, W. and Cui, M. (2017) Cadmium, lead, and arsenic contamination in paddy soils of a mining area and their exposure effects on human HEPG2 and keratinocyte cell-lines. Environmental Research, 156. pp. 23-30.

[img]
Preview
Text
Will Hartley effect of cadmium, lead 10 March 17 upload.pdf - Accepted Version
Available under License Creative Commons Attribution Non-commercial Share Alike.

Download (1MB) | Preview
Official URL: https://doi.org/10.1016/j.envres.2017.03.014

Abstract

A mining district in south China shows significant metal(loid) contamination in paddy fields. In the soils, average Pb, Cd and As concentrations were 460.1, 11.7 and 35.1 mg kg−1 respectively, which were higher than the environmental quality standard for agricultural soils in China (GB15618-1995) and UK Clea Soil Guideline Value. The average contents of Pb, Cd and As in rice were 5.24, 1.1 and 0.7 mg kg−1 respectively, which were about 25, 4.5 or 2.5 times greater than the limit values of the maximum safe contaminant concentration standard in food of China (GB 2762-2012), and about 25, 10 or 1 times greater than the limit values of FAO/WHO standard. The elevated contents of Pb, Cd and As detected in soils around the factories, indicated that their spatial distribution was influenced by anthropogenic activity, while greater concentrations of Cd in rice appeared in the northwest region of the factories, indicating that the spatial distribution of heavy metals was also affected by natural factors. As human exposure around mining districts is mainly through oral intake of food and dermal contact, the effects of these metals on the viability and MT protein of HepG2 and KERTr cells were investigated. The cell viability decreased with increasing metal concentrations. Co-exposure to heavy metals (Pb+Cd) increased the metals (Pb or Cd)-mediated MT protein induction in both human HepG2 and KERTr cells. Increased levels of MT protein will lead to greater risk of carcinogenic manifestations, and it is likely that chronic exposure to metals may increase the risk to human health. Nevertheless, when co-exposure to two or more metals occur (such as As+Pb), they may have an antagonistic effect thus reducing the toxic effects of each other.

Item Type: Article
Keywords: Arsenic, Cadmium, Cell exposure effects, Lead, Soil contamination
Divisions: Crop and Environment Sciences
Depositing User: Ms Kath Osborn
Date Deposited: 29 Mar 2017 13:38
Last Modified: 15 Mar 2018 05:10
URI: http://hau.collections.crest.ac.uk/id/eprint/15540

Actions (login required)

Edit Item Edit Item